...
Abstract – The crystal structure of porin from Rhodobacter capsulatus has been refined using the simulated annealing method.
...
| 3d molecule macro | ||||
|---|---|---|---|---|
|
...
1YCR
Abstract – The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the 109-residue amino-terminal domain of MDM2 bound to a 15-residue transactivation domain peptide of p53 revealed that MDM2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic alpha helix.
...